Editorial: Signaling Pathways in Embryonic Development

Editorial: Signaling Pathways in Embryonic Development

The Role of miRNA Dysregulation in Thyroid Cancer Development by Targeting the Main Signaling Pathways

Thyroid cancer is one of the most common malignancies of endocrine glands, causing carcinomas, such as papillary, follicular, medullary, and anaplastic thyroid carcinomas. Due to the significance of thyroid carcinomas, identification of the main signaling pathways and  the affecting mutations has been considered by researchers. Further studies on the dysregulation of oncogenes in signaling path...

Wnt Signaling in Embryonic Development

Researchers studying the Wnt pathway frequently like to joke that ‘Wnts do everything’, and that this fact keeps us all in business. Over time, this claim has become less facetious, as the number of known roles for Wnt signaling has grown rapidly. Following on from the first identified functions of Wnts in embryonic tissue patterning and cell proliferation, these signals and their multiple down...

Signaling dynamics and embryonic development

During embryonic development, signaling molecules convey positional information within the embryo and direct cells to adopt particular fates. A crucial question is how do the receiving cells of the embryo interpret these signals? While most work on this issue has focused on the biochemical and genetic dissection of the molecular circuitry of signal transduction, understanding signaling as a dyn...

Controversies in cancer stem cells: targeting embryonic signaling pathways.

Selectively targeting cancer stem cells (CSC) or tumor-initiating cells (TIC; from this point onward referred to as CSCs) with novel agents is a rapidly emerging field of oncology. Our knowledge of CSCs and their niche microenvironments remains a nascent field. CSC's critical dependence upon self-renewal makes these regulatory signaling pathways ripe for the development of experimental therapeu...